What We’re Writing

Differential disease tolerance mediates sex-biased illness severity in sepsis.
Breenna Dobson^†, Kathryn Strayer, Ayesha Wijesinghe, Jared Schlechte, Oscar Tejada, Alexandria Bartlett, Matthew Stephens, Diana Changirwa, Nicole A Cho, Ian-Ling Yu, Nargis Khan, Braedon McDonald^*
Proc Natl Acad Sci U S A 2026;123(9):e2522764123. | PMID: 41734079 | DOI : 10.1073/pnas.2522764123

Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections.
Nicole A Cho^†, Jared Schlechte, Ian-ling Yu, Ish Bains, Tanner Fahlman, Colin Mackenzie, Braedon McDonald^*
Intensive Care Med Exp 2026;14:9. | PMID: 41591701 | DOI : 10.1186/s40635-026-00860-1

Pathogenesis and therapeutic opportunities of gut microbiome dysbiosis in critical illness.
Nicole A Cho^†, Kathryn Strayer, Breenna Dobson, Braedon McDonald^*
Gut Microbes 2024;16(1):2351478. | PMID: 38780485 | DOI : 10.1080/19490976.2024.2351478

Dysbiosis of a microbiota-immune metasystem in critical illness is associated with nosocomial infections.
Jared Schlechte^†, Amanda Z Zucoloto, Ian-Ling Yu, Christopher J Doig, Mary J Dunbar, Kathy D McCoy, Braedon McDonald^*
Nat Med 2023;29(4):1017-1027. | PMID: 36894652 | DOI : 10.1038/s41591-023-02243-5

Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk.
Amanda Z Zucoloto^†, Jared Schlechte, Aline Ignacio, Carolyn A Thomson, Shannon Pyke, Ian-Ling Yu, Markus B Geuking Kathy D McCoy, Bryan G Yipp, Mark R Gillrie, Braedon McDonald^*
Cell Rep 2023;42(5):112507. | PMID: 37195866 | DOI : 10.1016/j.celrep.2023.112507

Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota.
Jared Schlechte^†, Isla Skalosky^†, Markus B Geuking, Braedon McDonald^*
Mucosal Immunol 2022;15(5):809-818. | PMID: 35732817 | DOI : 10.1038/s41385-022-00539-2

A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies.
Rachita Panda^†, Fernanda Vs Castanheira^†, Jared M Schlechte^†, Bas Gj Surewaard, Hanjoo Brian Shim, Amanda Z Zucoloto, Zdenka Slavikova, Bryan G Yipp, Paul Kubes, Braedon McDonald^*
JCI Insight 2022;7(2):e152291. | PMID: 34908534 | DOI : 10.1172/jci.insight.152291